Just after 5pm on December 25, police were called to reports of a possible homicide on Pine Ridge Road, in Arkansas.
In a statement, officers said upon arriving they found the bodies of five dead women inside a house.
The victims were aged between eight-years-old and 50-years-old - two were adults, three were juveniles.
They have not been identified and it is not known how long they were deceased before they were found.
It is believed all five victims are related, Sheriff Shane Jones said.
While the investigation is in the early stages, there is a chance the murders were “domestic related”, he said.
Sheriff Jones said the bodies were found by a family member and will undergo autopsies.
When asked by a reporter whether police have an idea of what the motive was, Sheriff Jones said no.
“Right now we're still learning, and that's an answer we might not ever get,” he said.
“At this time, we believe this to be an isolated incident, and do not feel that there is any continued danger to the local public,” the sheriff’s office said.
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