Gareth Southgate has brought in Aaron Ramsdale, Lewis Dunk, Kieran Trippier, Kalvin Phillips, Phil Foden and Marcus Rashford for the high-profile clash at Hampden Park on Tuesday evening.
Kyle Walker, Marc Guehi, Declan Rice, Jude Bellingham and Harry Kane are the five players to retain their starting berths following Saturday’s drab 1-1 draw with Ukraine in Poland in Euro 2024 qualifying.
Trippier is the only spare full-back in the squad and replaces Ben Chilwell, while Dunk is in for Harry Maguire at centre-back as Southgate sticks with Crystal Palace’s Marc Guehi.
Jordan Henderson's inclusion against Ukraine was controversial but he drops out here, with Kalvin Phillips starting alongside Declan Rice in midfield.
Foden and Rashford deputise for James Maddison and Bukayo Saka, with the former having failed to sparkle on his first competitive start against Ukraine in Wroclaw.
England XI: Ramsdale, Walker, Guehi, Dunk, Trippier, Phillips, Rice, Foden, Bellingham, Rashford, Kane
Subs: Johnstone, Pickford, Chilwell, Henderson, Maguire, Tomori, Saka, Eze, Colwill, Maddison, Gallagher, Wilson, Nketiah
Injuries: Alexander-Arnold, Grealish, Mount, Shaw, James, Stones
Time and date: 7.45pm BST, Tuesday September 12, 2023
Venue: Hampden Park