Star West Coast midfielder Tim Kelly will miss up to five weeks with a knee injury, while defender Alex Witherden has been ruled out for another month.
Kelly suffered a grade-two medial ligament strain to his right knee in last week's 16-point AFL loss to Essendon and will need to wear a brace for several weeks.
West Coast expect him to miss between four to five weeks.
The news wasn't good for Witherden either.
The former Brisbane defender has missed the past two matches with a groin issue and is expected to be sidelined for another month.
"Alex had a gentle walk-jog yesterday and tolerated that well but he's got a slow progression. We won't rush that and just monitor his response to each of those progressions," Eagles physiotherapist Mark Finucane said.
Swingman Oscar Allen has been ruled out of this week's clash with Carlton due to concussion.
West Coast stars Luke Shuey (hamstring) and Jeremy McGovern (knee) are still several weeks away, leaving the team light on A-graders.
Defender Liam Duggan (knee) is also sidelined while Daniel Venables (concussion) and Jarrod Cameron (ankle) have been ruled out for the season.
But West Coast midfielder Dom Sheed says the club's star-studded injury list is no excuse for the team's poor form and costly late fadeouts.
The Eagles coughed up a 29-point lead on the way to a shock loss to Essendon.
It was reminiscent of West Coast's 20-point loss to St Kilda in round four, when they led by 33 points in the third quarter before falling in a hole.
West Coast's second loss on the trot has left them clinging to seventh spot with a 6-5 record - two wins and 24 per cent adrift of fourth spot.
Essendon won the inside 50m count 22-6 in the final quarter despite the ruck dominance of Nic Naitanui.
Sheed said there were no excuses for the fadeout.
"I don't want to come in here and make injuries our excuse for losing because as much as we do lack personnel at the moment we play a system type of football," Sheed said.
"It doesn't matter who's playing that role we expect them to do it to the best of their ability and get the job done.
"It would be nice to get some of our top-end players back, but that's not an excuse.
"The gut part of it is how bad do you want it. The stats don't look good in the last quarter and we're working on that.
"I think our boys are hungry and we want to win. Maybe other teams just wanted it a little bit more than us."