The number of new coronavirus cases fell everywhere in the world last week by about 12 per cent, according to the World Health Organisation's latest weekly review of the pandemic.
The United Nations health agency reported that there were about 4.2 million new infections last week and about 13,700 deaths - a 5 per cent drop.
"This is very encouraging but there is no guarantee these trends will persist," WHO director-general Tedros Adhanom Ghebreyesus said at a press briefing.
"The most dangerous thing is to assume (that) they will," he said.
He added that even though the number of weekly reported deaths have plummeted more than 80 per cent since February, one person still dies with COVID-19 every 44 seconds and that most of those deaths are avoidable.
In its pandemic report, the WHO said COVID-19 deaths dropped in Southeast Asia, Europe and the Middle East but increased in Africa, the Americas and the western Pacific.
Maria Van Kerkhove, the WHO's technical lead on COVID-19, noted that the virus has not yet settled into a seasonal pattern and that its continued evolution will require constant surveillance and possible tweaks to diagnostics, treatments and vaccines.
Scientists warn the coronavirus will linger far into the future, partly because it is getting better and better at getting around immunity from vaccination and past infection.
Experts point to emerging research that suggests the latest Omicron variant gaining ground in the US - BA.4.6, which was responsible for about 8 per cent of new US infections last week - appears to be even better at evading the immune system than the dominant BA.5.
In China, authorities this week locked down 65 million of its citizens under tough COVID-19 restrictions and is discouraging domestic travel during the upcoming holiday period.
Across the country, 33 cities including seven provincial capitals are under full or partial lockdown covering more than 65 million people, according to a tally published late on Sunday by the Chinese business magazine Caixin.
It said that outbreaks have been reported in 103 cities, the highest since the early days of the pandemic in early 2020.