Ole Gunnar Solskajer’s side are riding high on momentum after their 2-0 victory against Chelsea on Monday.
Meanwhile, Odion Ighalo could make his first start for the club after a brief cameo at Stamford Bridge.
Brugge currently lead Gent by nine points in the Belgian Premier League, however, they are now without Sander Berge after selling their star midfielder to Sheffield United in January.
Here is everything you need to know:
When is it?
The match kicks off at 17.55 at Jan Breydel Stadium on Thursday 20 February.
How can I watch it?
The game will be broadcast live on BT Sport 2.
Brugge: Mignolet, Mata, Kossounou, Mechele, Deli, Rits, Balanta, Vanaken, Bonaventure, Tau, De Cuyper
United: Romero, Dalot, Lindelof, Maguire, Shaw, Williams, Matic, Mata, Pereira, Lingard, Martial
Brugge – 15/8
Draw – 21/10
United – 7/5