Ole Gunnar Solskjaer's side are on the up after beating Chelsea 2-0 at Stamford Bridge, narrowing the gap on the top four to just three points.
Meanwhile, Odion Ighalo could make his full debut for the club if Solskjaer looks to rotate his squad ahead of Sunday's fixture against Watford.
Brugge are runaway leaders in Belgium, nine points clear of Gent, but are dealing with the loss of their star midfielder Sander Berge to Sheffield United.
Here is everything you need to know:
When is it?
The match kicks off at 17.55 at Jan Breydel Stadium on Thursday 20 February.
How can I watch it?
The game will be broadcast live on BT Sport 2.
Brugge: Mignolet, Mata, Kossounou, Mechele, Deli, Rits, Balanta, Vanaken, Bonaventure, Tau, De Cuyper
United: Romero, Dalot, Lindelof, Maguire, Shaw, Williams, Matic, Mata, Pereira, Lingard, Martial
Brugge - 15/8
Draw - 21/10
United - 7/5