Both teams have a host of absences to contend with—and PSG manager Thomas Tuchel also broke a bone in his foot at the weekend, but will still be present for the game.
The Serie A outfit beat Valencia in the last round to reach this point, while the French Ligue 1 side dispatched of Borussia Dortmund.
From this point onward in the competition all games are held in Portugal.
Here’s all you need to know about the game.
When is it and what time is kick-off?
The match will begin at 8pm BST on Wednesday 12 August at the Estadio da Luz, Lisbon.
How can I watch it online and on TV?
The game will be broadcast live on BT Sport 1 and BT Sport Extra 1, as well as BT Sport Ultimate.
Subscribers can also stream the match on the BT Sport website and app.
Atalanta: Sportiello, Toloi, Caldara, Djimsiti, Hateboer, de Roon, Freuler, Gosens, Papu Gomez, Pasalic, Zapata
PSG: Navas, Kehrer, Silva, Kimpembe, Bernat, Gueye, Marquinhos, Herrera, Sarabia, Icardi, Neymar
Atalanta — 11/5
Draw — 3/1
PSG — 23/18
PSG would be far more comfortable if Mbappe and Marco Verratti in particular were available, but the two big misses at either end of the pitch for Atalanta could prove key.
Atalanta 2-3 PSG