Stocks have fallen, while government bonds and the US dollar have risen as anxious investors fled risk assets after Russian President Vladimir Putin ordered a partial mobilisation and accused the West of "nuclear blackmail".
European equity markets dropped sharply, with the benchmark euro zone STOXX 50E index falling by 1 per cent at one point to a two-month low, which in turn dented US emini stock futures, which pared overnight gains to trade roughly unchanged on the day, suggesting a flat start on Wall Street later.
European currencies came under fire, with the euro dropping 0.56 per cent to $0.9913 and sterling last down 0.31 per cent at $1.1345, after having touched a new 37-year low at $1.1304.
The dollar index, which measures the currency against six major peers, rallied 0.41 per cent to 110.62, just below a fresh two-decade high of 110.87.
The dollar eased modestly against the Japanese yen, another safe-haven currency, dropping 0.1 per cent to 143.58.
With the US Federal Reserve due to deliver another aggressive rate hike later in the day, in a week packed with major central bank decisions, key market measures of volatility neared multi-week highs.
"Obviously we have a situations where investors flock to safe havens and we've also got the anticipation that we are going to see another rate hike from the Federal Reserve today," Danni Hewson, a financial analyst at AJ Bell said.
"So the dollar was already looking quite punchy and clearly just the proximity to Ukraine of countries in Europe does make people consider what the situation might look like if the war in Ukraine becomes something bigger. So it's a double edged sword, which is impacting the euro, sterling and the dollar in different ways."
Putin said he had signed a decree on partial mobilisation beginning on Wednesday, saying he was defending Russian territories and that the West wanted to destroy the country.
"If the territorial integrity of our country is threatened, we will use all available means to protect our people - this is not a bluff," Putin said in a televised address to the nation, adding Russia had "lots of weapons to reply".
"It's the fact that he's decided to dust off the nuclear card that obviously hasn't gone down well, and the euro has really been feeling the effects of that as well," Michael Hewson, chief markets strategist at CMC Markets in London, said.
Equities were already under pressure given the jitters around the Fed's upcoming policy decision at which it is widely expected to lift rates by three quarters of a point.
The MSCI All-World index of global shares dropped 0.4 per cent to skim two-month lows, while gold, another traditional safe-haven, gained 0.5 per cent to trade around $1,667.40 an ounce, set for its largest one-day rally in over a week.
In Asia overnight, Japan's Nikkei fell 1.36 per cent and touched a two-week low, while Chinese blue chips declined 0.71 per cent, and Hong Kong's Hang Seng lost 1.48 per cent.
The Fed headlines a week in which more than a dozen central banks announce policy decisions, including the Bank of Japan and Bank of England on Thursday.
Sweden's Riksbank surprised markets overnight with a full percentage-point hike, and warned of more to come over the next six months.
As traders and investors have ratcheted up their expectations for central banks to raise interest rates to quell persistent inflation, global bond yields have soared in recent months.
But with nerves over Russia running high, so did demand for the comparative safety of government debt.
German 10-year Bund yields dropped 9 basis points to around 1.854 per cent, on course for their largest one-day drop in a month, having hit their highest since early 2014 the day before.
The 10-year Treasury yield touched 3.604 per cent on Tuesday for the first time since April 2011 before retreating to 3.532 per cent after Putin's comments.