Aubameyang struck 16 minutes before full-time to spare Arsenal’s blushes on Thursday and kick their Europa League campaign off with a 2-1 win.
Mikel Arteta has made changes from that win in Austria, with Kieran Tierney and Hector Bellerin coming back in.
In midfield, Thomas Partey keeps his place after a fine full debut on Thursday, with Dani Ceballos also in alongside Granit Xhaka.
The Spaniard, like Willian, was injured for the trip to Vienna, but the Brazilian remains out.
Arsenal XI: Leno, Bellerin, Luiz, Gabriel, Tierney, Ceballos, Xhaka, Partey, Saka, Lacazette, Aubameyang
Subs: Runarsson, Maitland-Niles, Pepe, Mustafi, Elneny, Willock, Nketiah
Leicester XI: Schmeichel, Fofana, Evans, Fuchs, Castagne, Tielemans, Mendy, Justin, Praet, Maddison, Barnes
Subs: Morgan, Vardy, Albrighton, Ward, Iheanacho, Under, Choudhury
Referee: Craig Pawson