The Gunners were forced to work hard for their 2-2 draw at Stamford Bridge, playing for more an hour with ten men following Luiz’s 26th-minute dismissal, and although they have six days to recover, Arteta is likely to rotate to some extent.
Sokratis is hopeful of returning from illness to feature and Arteta must decide whether to restore the Greek centre-back or continue with Shkodran Mustafi, who recovered well after his error against Chelsea.
Rob Holding made his first start in almost two months against Leeds in the previous round and needs games.
Arteta is keen to involve Reiss Nelson where possible and the winger could come into the team while Gabriel Martinelli is surely too good to leave out at the moment after carrying the fight against Chelsea, scoring against the Blues three days after netting against Sheffield United.
Predicted Arsenal XI (4-2-3-1): Martinez, Maitland-Niles, Sokratis, Holding, Kolasinac; Xhaka, Guendouzi; Nelson, Ozil, Martinelli; Lacazette