The 36-year-old has withdrawn ahead of the qualifying draw at Roland Garros but plans to play at Queen’s next month and potentially another Wimbledon warm-up event at Surbiton.
Murray suffered first-round exits on the clay in Monte Carlo, Madrid and Rome, before winning the Aix-en-Provence Challenger to secure his first title at any level since 2019.
But the Scot suffered a 6-3, 6-0 defeat to old foe Stan Wawrinka at a Challenger event in Bordeaux last week and has decided to focus on his preparation for Wimbledon.
Speaking after that loss to Wawrinka, Murray said: "It’s not so much about [physical worries]. I trust that my body will be okay after what I did at the beginning of the year. I played back-to-back five-hour matches and did well physically in those matches. There’s no reason why that should necessarily be any different here.
"It was just more to see where my game is at. It’s just what the right thing is to prioritise at this stage in my career. I trust my body now but I’m aware that my best chance of having a deep run is more likely to happen at Wimbledon."
Murray is the latest big name to pull out of the French Open, following Rafael Nadal and Nick Kyrgios.