RSPCA inspectors seized 132 animals from a suburban Perth property yesterday.
Inspectors had been told there were a large number of animals living in unhygienic conditions.
All of the animals, including cats, rabbits and birds, are in RSPCA care and many require veterinary attention.
The big influx of animals has forced the RSPCA's Malaga headquarters to temporarily suspend its adoption and retail services.
"This appears to be a sad and unfortunate situation. I want to pay tribute to the work of RSPCA Inspectors," RSPCA CEO David van Ooran said.
"Our Inspectors worked all day and through the night to make sure the 132 animals that were located at the property were safe in RSPCA care.
"Our shelter staff also worked through the night to look after the animals and make them comfortable.
"I would like to thank our supporters for their patience and understanding. RSPCA has been overwhelmed with offers of help from the public and we are extremely grateful.
"The public can help the RSPCA via donations which will help purchase enrichment toys for the cats, rabbits and birds which are likely to remain in RSPCA care for some time." RSPCA CEO David van Ooran said.
To pledge support, people can visit www.rspcawa.asn.au and click on the donate button.