Veteran East Perth forward Michael Swan, Swan Districts premiership wingman Tom Roach and Claremont forwards Paul Medhurst and Chad Jones have all retired.
Both Medhurst (2001) and Jones (2009 and 2010) claimed the Bernie Naylor Medal as the WAFL's leading goal kicker, with Medhurst awarded the Simpson Medal as best player afield in the Tigers' grand final win against East Fremantle last year.
A member of Tigers premierships in 2011 and 2012, Jones, 29, notched 129 games in 11 seasons while 31-year-old Medhurst played 66 matches in five.
Swan, 32, played 171 games in 11 WAFL seasons.
Royals football manager Mark Winnett said it was unfortunate Swan, captain of East Perth from 2006-2012, couldn't have finished his career with a win over West Perth in last Sunday week's grand final.
"Swanny came over from Port Melbourne to play with his brother, captained the club for seven years and had an integral role in our leadership group again this year," Winnett said.
"It would have been great to get a premiership for him."
Roach played 81 WAFL matches and two State games in four seasons, and was a member of the Swans side which beat Claremont by one point in the 2010 grand final.
The 28-year-old also represented WA against Victoria (2010) and Queensland (2011).
Swans football operations manager Phil Smart said it was hoped Roach would not be lost to the club in 2014, possibly staying on at the club as an assistant coach with the colts.
"Tom might change his mind but he's retired at the moment," Smart said."He's been a great player for our club, a premiership player in 2010, and a quality person."