A man is in hospital after a suspected drug lab explosion in Busselton last night.

Busselton Senior Sergeant Steve Principe said police, St John Ambulance and the Department of Fire and Emergency Services were called to a granny flat in Vasse about 5.15pm after a loud explosion was reported.

The only person in the property at the time was a 34-year-old man, who was taken to Busselton Hospital with burns to his arms and legs.

Sen. Sgt Principe said the Organised Crime Squad would search the premises this morning to determine the cause of the explosion.