Wild dogs in their current “plague proportions” will close Kybo Station, 500km east of Kalgoorlie-Boulder.
Station owner Rod Campbell says he has shot 150 wild dogs and pulled the same number from traps, since November.
He must fulfil an export contract for 2000 fat-tailed sheep at $100 a head next month, but he is not sure the numbers will add up at muster.
Mr Campbell said if the contract falls through the 48-year-old station on the edge of the Nullarbor will go under.
At last muster the station ran about 7000 sheep, but since then an unknown number has been taken by the dogs.
Aside from being killed outright, the sheep are often injured by dog attacks and become flyblown, or they grow stressed and refuse to lamb.