The vulnerability of the Goldfields' main transport route was again exposed as a truck rollover forced the Great Eastern Highway’s closure for nearly 18 hours on the weekend before Christmas.

The closure came after a road train, carrying two trailers with numerous chemicals and substances, crashed about 75km west of Coolgardie just before 2.20am on Saturday.

The driver and passenger were freed through the windscreen and taken by ambulance to Kalgoorlie Hospital where they were treated for minor injuries and released.

A clean-up crew, which included a haulage recovery vehicle from Perth and a crane, carried out the laborious task of removing the wreckage and cleaning a dangerous spill of sodium cyanide and diesel fuel on the road.

The road train was travelling from Perth and was carrying a number of chemicals including perchloric acid, isopropyl alcohol and ethanol.