Fires that have burnt 40,000 hectares in Victoria's Mallee region are expected to continue through the weekend.
Several bushfires are burning out of control in the Mallee with firefighters bracing for the aftermath of a strong southwesterly wind change Friday evening.
Fire Services Commissioner Craig Lapsley said the fires were now 40,000 hectares in size.
He said it would be a very difficult fire for firefighters once the strong south-westerly wind change moved through.
"We could only hope that they get on top of it by the end of the day but our assessment is this fire will continue to be a going fire into tomorrow and the weekend," he said on Friday.
Twelve aircraft and six dozers are supporting about 300 firefighters in the battle to control the blazes occurring mainly in parkland and reserves.
The towns of Tempy and Gypsum on Friday afternoon received their second emergency warning in as many days, with Pier Milan also on alert, before the advice was downgraded.
Hopetoun West, Hopevale and Kenmare were put on an emergency alert for Friday evening with a bushfire headed south from Paradise Flora and Fauna Reserve towards Kenmare.
Residents in all the towns are being told that leaving their homes is the safest option and relief centres have been set up in Beulah and Ouyen.
Mildura incident controller Damian Kerr said crews worked in difficult conditions to contain several major blazes before the strong south-westerly change and another day of severe weather conditions in the state's northwest on Saturday.
Visibility in the area was low, and the Sunraysia Highway was closed between the Calder Highway and the township of Speed.
Firefighters were also focusing on a 20,000-hectare blaze in the Big Desert Wilderness Park near the South Australian border.
That fire was impacting on the Red Bluff Flora and Fauna Reserve.
Firefighters were battling a number of other fires which have merged near the Lake Albacutya Freeway Track in south-eastern Wyperfeld.
Fires are also burning near Rocket Lake in Murray Sunset National Park and next to Underbool Track in Wyperfeld National Park.
Both national parks have been closed along with Hattah Kulkyne National Park.
Authorities are urging people to stay informed and travellers in the area should plan their trip.