The Perth brother of an ABC employee who vanished on her way home from a night out in Melbourne believes he was the last person to speak to her.
Jillian Meagher was about 700m from home when she left a bar in Brunswick about 1.30am on Saturday to walk home alone.
She did not make it.
Her brother Michael McKeon, who has flown to Victoria to help search for his sister, said he spoke briefly to Ms Meagher when she called him in Perth between 1.45am and 2am (Melbourne time) and it sounded like she was headed home.
Mr McKeon told a Melbourne newspaper his sister had been worried about their father, who recently had a stroke, and called to check on him.
Their mother Edith McKeon reportedly said her son heard people in the background as they spoke.
The call ended and he tried to call her back a few times but she did not answer.
The homicide squad took over the investigation into the 29-year-old's disappearance yesterday and Det-Insp. John Potter said he feared Ms Meagher met with foul play.
Police scoured a Brunswick lane after her black handbag with identification documents was found early yesterday.
Det-Insp. Potter said the lane was off a street Ms Meagher might have taken on her way home and police were reviewing CCTV footage and trying to retrace her steps.
Ms Meagher has not accessed her bank account and Det-Insp. Potter could not confirm whether police had found her phone, which had been switched off.
She had been drinking with friends for several hours at a Brunswick pub on Friday night before some of them moved on to nearby Bar Etiquette.
She left there about 1.30am, refusing an offer by colleague Tom Wright to accompany her home.
Mr Wright said he asked if she wanted him to walk her home because it was late but she said: "No, no I live around here, I know it really well, don't worry."
Det-Insp. Potter said Ms Meagher spoke to her husband Thomas earlier and he went searching for her when she did not arrive home.
He said the area where she went missing would have been busy at that time of the morning.
Mr Meagher told radio 3AW he called his wife's phone "non-stop" from 2am to 6am on Saturday and went looking for her about 4am.
He and Mr McKeon contacted everyone she knows for help to find her and put up flyers where she disappeared. Friends and relatives were making appeals on Facebook and Twitter.
Mrs McKeon, who lives in Attadale, made a plea yesterday for her return.
"Jillian, Jillian, please, please, please come home and whoever . . . just let her go," she told Ten News.
Mr McKeon said his sister was fun-loving, always positive and that her disappearance was out of character.