Emergency crews are clearing human waste from a major Brisbane road, after it spilled from a truck this morning.

Street sweepers and vacuum trucks are cleaning up faeces on the southbound lanes of Southern Cross Way, near the Gateway Bridge.

Fire and rescue squads were called to the scene when the vehicle's contents spilled onto the road at approximately 7:30am (AEST).

Transport company Transpacific Industries said the truck lost power steering and hit a guard rail before causing a mess and delays for this morning's commuters.

The truck was carrying a 'key component of organic fertiliser', according to a company spokesperson.

No injuries were reported as a result of the mishap.